Zymosan-mediated inflammation impairs in vivo reverse cholesterol transport
نویسندگان
چکیده
منابع مشابه
Inflammation impairs reverse cholesterol transport in vivo.
BACKGROUND Inflammation is proposed to impair reverse cholesterol transport (RCT), a major atheroprotective function of high-density lipoprotein (HDL). The present study presents the first integrated functional evidence that inflammation retards numerous components of RCT. METHODS AND RESULTS We used subacute endotoxemia in the rodent macrophage-to-feces RCT model to assess the effects of inf...
متن کاملMast cell activation in vivo impairs the macrophage reverse cholesterol transport pathway in the mouse.
OBJECTIVE Chymase released by activated mast cells degrades high-density lipoproteins. We evaluated whether local activation of mast cells would attenuate cholesterol efflux from neighboring macrophage foam cells, thereby disrupting the entire in vivo pathway of macrophage-specific reverse cholesterol transport (RCT). METHODS AND RESULTS C57Bl/6J mice received intraperitoneal injections of th...
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HDL protects against vascular disease by accepting free cholesterol from macrophage foam cells in the artery wall. This pathway is critically dependent on lecithin:cholesterol acyltransferase (LCAT), which rapidly converts cholesterol to cholesteryl ester. The physiological activator of LCAT is apolipoprotein A-I (apoA-I), the major HDL protein. However, cholesterol removal is compromised if ap...
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Atherosclerosis is a progressive disease characterized by the appearance of inflamed lesions in the arterial wall. The main component of an atherosclerotic lesion is a cholesterol-filled macrophage (a foam cell). In addition, the inflamed intima contains numerous mast cells which, upon activation, acutely secrete serine proteases and other mediators that can influence the progression of atheros...
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Atherosclerosis is characterized by a chronic inflammatory condition, in which numerous cellular and molecular inflammatory components are involved. A wide array of inflammatory mediators, such as cytokines and proteins produced by macrophages and other cells, play critical roles in the development and progression of the disease. ABCA1 is crucial for cellular cholesterol efflux and reverse chol...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2011
ISSN: 0022-2275
DOI: 10.1194/jlr.m011122